Pyrrole Disorder (or Pyroluria) is a genetic blood disorder, a chemical imbalance, involving an abnormality in haemoglobin synthesis. It is a familial condition, caused by poor genetics (such as familial alcoholism) and/or by environmental toxicity. It can be induced by childhood trauma or chronic infection early in life. The onset commonly occurs during the late teens and continues throughout a person’s life, triggered by a traumatic incident – death of a loved one, parental divorce, moving away to college, etc. The disorder is highly aggravated by prolonged stress, for instance during injury, oxidative stress or chronic or debilitating illness. It is estimated that approximately 10% of the population have Pyrrole Disorder (or Pyroluria), with estimates as high as 20% of all psychiatric patients and 40% of all schizophrenic patients, with a higher prevalence in women than men. Pyrrole disorder is caused by the overproduction of hydroxyhempyrolin (HPL). The HPL binds zinc and B6 preventing their use by the body and causing excretion in the urine and hair. HPL is a biomarker for oxidative stress and is neurotoxic. Stress of any kind will increase production of pyrroles/HPL which in turn decreases zinc and B6. The main biochemical features are of severe zinc and B6 deficiency. Zinc is essential for 100’s of processes in the body and is particularly important for healing, immune function, digestion, neurotransmitter activation, physical growth, memory, insulin sensitivity, and control of blood sugars, DNA replication and more…. Zinc and B6 are essential for production of neurotransmitters such as serotonin (our happy hormone), melatonin (our sleep hormone), GABA (our relaxation hormone), and acetyl choline which is important for memory. They are also involved in production of our steroid hormones such as cortisol (our anti-inflammatory, anti-allergy hormone and stress hormone) and the conversion of oils in the body (fat metabolism, liver and gall bladder issues and weight control). The oils EPA/DHA but mostly GLA are found to be low in those with pyrrole disorder and are damaged by oxidative stress/free radicals/toxins created by pyrrole.
Considering the many symptoms associated with this disorder, it amazes me that hardly anyone seems to know about it (yet). For your convenience, here’s a list of the signs and symptoms associated with it. If you suffer from several or many of these, it may be a good idea to get tested for it. For more information on getting tested for Pyrrole Disorder, click here.
Physical Signs of Pyrrole Disorder:
- White spots on fingernails
- Unusual fat distribution (larger mid-section)
- Sweet, fruity breath and body odour
- Pale skin that burns easily
- Overcrowded teeth and poor tooth enamel
- Increased incidence of stretch marks
- Creaking knees
- Cold hands and feet, even in summer
Common Symptoms of Pyrrole Disorder:
- Spleen pain (located on the left side of your abdomen, below the ribs – the pain tends to spread to the back)
- Stitch in side
- Food Intolerances (particularly gluten, dairy and sulphur)
- Food/environmental allergies
- Irritable bowel syndrome and other digestive problems
- Joint pains and knee problems
- Poor dream recall
- Auditory processing disorder (ie not hearing properly with background noises)
- Delayed onset of puberty
- Impotence in men
- Irregular menstruation
- Increased sensitivity to sound, light, smell and touch
- Craving for high-sugar and high-carb foods
- Sensitivity to medications and chemicals
- Low stress tolerance
- Mood swings
- Motion sickness
- Memory loss
- Temper outbursts
Sources and read more about Pyrrole Disorder:
During a verbal consultation, my doctor told me that the chances of getting cancer for someone with Pyrrole Disorder are much higher than normal. I figured I better nip this in the bud before things get out of hand… She also mentioned there was not only the typical deficiency of Vitamin B6 and zinc but also a tendency towards Vitamin D deficiency. I had my levels checked and I was very deficient. I was really surprised as I thought that living in one of the sunniest places on Earth should surely take care of my Vitamin D requirements, but she pointed out that (due to the Pyrrole Disorder) I was unlikely to ever have sufficient Vitamin D without supplementing it.
I came across this article about a university study, which associates IBS (one of the most common symptoms of Pyrrole Disorder) with Vitamin D deficiency:
Large Proportion Of IBS Sufferers Are Vitamin D Deficient (University of Sheffield)
There are important things to know when it comes to supplementing with Vitamin D (such as combining it with Vitamin K2 for example), and the best source of information in relation to this I found on this website: www.mercola.com. I highly recommend this site as it provides a tremendous amount of valuable information in relation to natural health and it comes with a powerful search engine. Search for any illness, nutrient or anything else that comes to mind and you will be amazed at the sheer amount of well researched articles you’ll come across (written by a fully qualified doctor who is one of the world’s leading experts in nutrition).
For example, look at the search results in relation to Vitamin D deficiency here.
What Really Made All The Difference To Me In The End:
I found that, while my doctor’s recommendations had resulted in some improvements, the real shift happened when I started taking very unique products that you may never even have heard of, such as special MORINGA-based formulas and pure Branch Chain Amino Acids (which made me stop feel any muscle pain after exercising – a massive help for me as I’d always felt like I’d tortured myself when I went to the gym, and now I feel fantastic afterwards!), trillions of special molecules that repair cells (I can’t refer to the product name due to the company’s policies where they don’t allow their product to be promoted alongside other products), Stem Cell Nutrition and Collagen Hydrolysate.
I also experiment with a multitude of energy devices such as scalar waves, Rife-technology-based equipment and EMF protection devices. Not ready yet to share this on my website, so please message me if you’re interested.
Note: I’m just sharing my personal experiences and information I found useful here. This information is not intended to diagnose, treat, prevent or cure any diseases and does not constitute medical advice. Please consult your health care professional before starting any new diet, exercise or use of supplements. Do not alter or discontinue any current medical treatment based on information provided.